母乳喂养不会增加乙型肝炎病毒垂直传播Breastfeeding cannot increase the vertical transmission of hepatitis B virus
周乙华;向宽辉;庄辉;
摘要(Abstract):
乙型肝炎病毒(hepatitis B virus,HBV)感染母亲能否母乳喂养其子女是重要的临床问题。本文总结了在使用乙型肝炎免疫预防前后,母乳喂养和人工喂养婴儿的HBV垂直传播率的相关研究。结果显示,尽管感染HBV的母亲乳汁中存在病毒,但2种喂养方式的垂直传播率相似,证明母乳喂养不增加垂直传播风险。结合母乳喂养对婴儿和母亲的各种益处,应鼓励感染HBV的母亲母乳喂养其子女。
关键词(KeyWords): 乙型肝炎病毒;垂直传播;母乳喂养
基金项目(Foundation): 国家自然科学基金资助项目(81672002)
作者(Authors): 周乙华;向宽辉;庄辉;
参考文献(References):
- [1]SETO W K,LO Y R,PAWLOTSKY J M,et al.Chronic hepatitis B virus infection[J].Lancet,2018,392(10161):2313-2324.
- [2]TERRAULT N A,LEVY M T,CHEUNG K W,et al.Viral hepatitis and pregnancy[J].Nat Rev Gastroenterol Hepatol,2021,18(2):117-130.
- [3]ZHOU Y H.Evidence against in utero transmission of hepatitis B virus[J].Nat Rev Gastroenterol Hepatol,2021,18(6):445.
- [4]Section on Breastfeeding.Breastfeeding and the use of human milk[J].Pediatrics,2012,129(3):e827-e841.
- [5]EIDELMAN A I.Breastfeeding and the use of human milk:an analysis of the American Academy of Pediatrics 2012 Breastfeeding Policy Statement[J].Breastfeed Med,2012,7(5):323-324.
- [6]TORRES ROLDAN V D,URTECHO S M,GUPTA J,et al.Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants[J].Am J Clin Nutr,2020,112(1):106-112.
- [7]BABIC A,SASAMOTO N,ROSNER B A,et al.Association between breastfeeding and ovarian cancer risk[J].JAMA Oncol,2020,6(6):e200421.
- [8]LINNEMANN C C J R,GOLDBERG S.Letter:HBAg in breast milk[J].Lancet,1974,2(7873):155.
- [9]LEE A K,IP H M,WONG V C.Mechanisms of maternal-fetal transmission of hepatitis B virus[J].J Infect Dis,1978,138(5):668-671.
- [10]WONG V C,LEE A K,IP H M.Transmission of hepatitis B antigens from symptom free carrier mothers to the fetus and the infant[J].Br J Obstet Gynaecol,1980,87(11):958-965.
- [11]HUANG H,NING M,FENG J,et al.Hepatitis B viral markers in the breast milk of HBsAg-positive mothers:an observational study[J].J Hum Lact,2021.Epub ahead of print.
- [12]中华医学会儿科学分会感染学组,《中华儿科杂志》编辑委员会.对乙型肝炎病毒母婴传播阻断的建议[J].中华儿科杂志,2008,46(4):263.
- [13]AHN J,SALEM S B,COHEN S M.Evaluation and management of hepatitis B in pregnancy:a survey of current practices[J].Gastroenterol Hepatol (N Y),2010,6(9):570-578.
- [14]戴鑫伟,周乙华,胡娅莉,等.妇产科医务人员对预防乙型肝炎病毒母婴传播知识的掌握情况调查[J].中华围产医学杂志,2013,16(7):429-436.
- [15]ALTER H J.The unexpected outcomes of medical research:serendipity and the Australia antigen.Blumberg BS,Alter HJ,Visnich S.A new antigen in leukemia sera[J Am Med Assoc 1965;191:541-546][J].J Hepatol,2003,39(2):149-152.
- [16]BEASLEY R P,STEVENS C E,SHIAO I S,et al.Evidence against breast-feeding as a mechanism for vertical transmission of hepatitis B[J].Lancet,1975,2(7938):740-741.
- [17]DERSO A,BOXALL E H,TARLOW M J,et al.Transmission of HBsAg from mother to infant in four ethnic groups[J].Br Med J,1978,1(6118):949-952.
- [18]KRUGMAN S,GILES J P,HAMMOND J.Viral hepatitis,type B (MS-2 strain) prevention with specific hepatitis B immune serum globulin[J].JAMA,1971,218(11):1665-1670.
- [19]KRUGMAN S.The newly licensed hepatitis B vaccine.Characteristics and indications for use[J].JAMA,1982,247(14):2012-2015.
- [20]WEI K P,ZHU F C,LIU J X,et al.The efficacy of two different dosages of hepatitis B immunoglobulin combined with hepatitis B vaccine in preventing mother-to-child transmission of hepatitis B virus:A prospective cohort study[J].Vaccine,2018,36(2):256-263.
- [21]潘明洁,徐陈瑜,刘兰华,等.母亲乙型肝炎表面抗原基因变异与新生儿免疫预防失败无关[J].中国病毒病杂志,2019,9(3):182-187.
- [22]娄海琴,朱继华,王志红,等.以产妇人群为基础的免疫预防乙型肝炎病毒母婴传播的现实世界效果[J].中华围产医学杂志,2019,22(8):591-596.
- [23]HILL J B,SHEFFIELD J S,KIM M J,et al.Risk of hepatitis B transmission in breast-fed infants of chronic hepatitis B carriers[J].Obstet Gynecol,2002,99(6):1049-1052.
- [24]ZHENG Y,LU Y,YE Q,et al.Should chronic hepatitis B mothers breastfeed?a meta analysis[J].BMC Public Health,2011,11:502.
- [25]SHI Z,YANG Y,WANG H,et al.Breastfeeding of newborns by mothers carrying hepatitis B virus:a meta-analysis and systematic review[J].Arch Pediatr Adolesc Med,2011,165(9):837-846.
- [26]XIAO F,LAN A,MO W.Breastfeeding from mothers carrying HBV would not increase the risk of HBV infection in infants after proper immunoprophylaxis[J].Minerva Pediatr,2020,72(2):109-115.
- [27]CHEN X,CHEN J,WEN J,et al.Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus[J].PLoS One,2013,8(1):e55303.
- [28]汪雪玲,李春梅,刘敏,等.不同喂养方式对乙型肝炎病毒母婴传播的影响[J].中华围产医学杂志,2015,18(8):616-620.
- [29]田瑞华,李星明,李高飞,等.高病毒载量乙型肝炎病毒感染孕妇孕期服用抗病毒药物后不同喂养方式对母婴传播的影响:一项前瞻性队列研究[J].中华围产医学杂志,2021,24(7):497-502.
- [30]罗志粦,郑逊.HBsAg阳性产妇母乳喂养与乙肝病毒母婴传播的相关性研究[J].福建医药杂志,2010,32(5):45-47.
- [31]王龙成,黄雪梅,李又平.母婴主、被动联合免疫阻断乙肝病毒垂直传播的临床观察[J].宁夏医学杂志,2010,32(2):178-179.
- [32]中华医学会感染病学分会,中华医学会肝病学分会.慢性乙型肝炎防治指南(2019年版)[J].中国病毒病杂志,2020,10(1):1-25.
- [33]中华医学会妇产科学分会产科学组,中华医学会围产医学分会.乙型肝炎病毒母婴传播预防临床指南(2020)[J].中华围产医学杂志,2020,23(5):292-301.
- [34]YEH R F,REZK N L,KASHUBA A D,et al.Genital tract,cord blood,and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected women[J].Antimicrob Agents Chemother,2009,53(6):2367-2374.
- [35]PALOMBI L,PIRILLO M F,MARCHEI E,et al.Concentrations of tenofovir,lamivudine and efavirenz in mothers and children enrolled under the Option B-Plus approach in Malawi[J].J Antimicrob Chemother,2016,71(4):1027-1030.
- [36]CHEN H L,LEE C N,CHANG C H,et al.Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus[J].Hepatology,2015,62(2):375-386.
- [37]冯静,李洁,刘景丽,等.羊膜腔穿刺对乙型肝炎病毒母婴传播的影响[J].中华围产医学杂志,2015,18(11):823-827.
- [38]JALALI L M,KOSKI K G.Amniotic fluid minerals,trace elements,and prenatal supplement use in humans emerge as determinants of fetal growth[J].J Trace Elem Med Biol,2018,50:139-145.
- [39]刘景丽,冯静,林晓倩,等.母乳与乙型肝炎表面抗原的结合特性[J].中华围产医学杂志,2016,19(2):114-118.
- [40]张昭萍,刘景丽,冯静,等.乙型肝炎表面抗原结合人乳中乳铁蛋白的筛选与鉴定[J].中华围产医学杂志,2019,22(7):457-460.
- [41]FLORIAN P E,MACOVEI A,LAZAR C,et al.Characterization of the anti-HBV activity of HLP1-23,a human lactoferrin-derived peptide[J].J Med Virol,2013,85(5):780-788.
- [42]LUO Y,SONG J,XIANG K,et al.Inhibition of hepatitis B virus (HBV) infection by human breast milk[C].厦门:中华医学会第十四次全国围产医学学术会议,2020.