SPB-C/A(18)基因多态性与中国新生儿支气管肺发育不良关系的荟萃分析Meta-analysis of the relationship between SPB-C/A(18) gene polymorphism and broncho-pulmonary dysplasia in Chinese newborn
马腾腾;王琨;柏金秀;张磊;王博玉;
摘要(Abstract):
目的探讨肺表面活性物质相关蛋白B(surfactant protein B,SPB)-C/A(18)基因多态性与中国新生儿支气管肺发育不良(broncho-pulmonary dysplasia,BPD)发病风险的相关性。方法利用中国知网、维普、万方、PubMed、Medline、Web of Science等数据库检索有关SPB-C/A(18)基因多态性与BPD相关性的病例对照研究,时限为1998年1月至2018年4月。根据纳入和排除标准选择文献,评估文献质量,并提取相关研究数据,采用Revman 5.3软件进行荟萃分析。结果共纳入5篇文献,观察组患儿332例,对照组患儿409例。荟萃分析显示:SPB-C/A(18)基因多态性与中国新生儿BPD发病风险无明显相关性(AA+AC与AA+AC+CC:OR=1.65,95%CI:0.90~3.03,P=0.10;A与A+C:OR=1.35,95%CI:0.72~2.53,P=0.34)。结论 SPB-C/A(18)基因多态性与中国新生儿BPD发病风险可能无明显相关性,但仍需大量高质量的研究进一步证实。
关键词(KeyWords): 基因多态性;荟萃分析;支气管肺发育不良;新生儿
基金项目(Foundation): 国家自然科学基金资助项目(81300052);; 保定市科技计划项目(17ZF234)
作者(Authors): 马腾腾;王琨;柏金秀;张磊;王博玉;
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