乙型肝炎表面抗原的发现
Anna S.Lok
摘要(Abstract):
<正>在20世纪60年代,Baruch S.Blumberg正致力于遗传学、不同人群的疾病遗传易感性和多态性系统研究。当时的观点认为,大量输血的患者常会针对供体血液中的"多态性血浆蛋白(polymorphic serum proteins)"产生抗体,因而Blumberg设想,通过"琼脂胶双向扩散(double diffusion in agar gel)"的方法,这些患者的血液样本可以用于鉴定不同人群的遗传多态性和疾病易感性。
关键词(KeyWords):
基金项目(Foundation):
作者(Author): Anna S.Lok
参考文献(References):
- [1]Blumberg BS,Alter HJ,Visnich S.A"new"antigen in leukemiasera[J].J Am Med Assoc,1965,191:541-546.
- [2]Blumberg BS,Melartin L,Guint RA,et al.Family studies ofa human serum isoantigen system(Australia antigen)[J].Am JHum Genet,1966,18(6):594-608.
- [3]Blumberg B,Gerstley B,Hungerfod D,et al.A serum antigen(Australia antigen)in Down's syndrome,leukemia,andhepatitis[J].Ann Intern Med,1967,66(5):924-931.
- [4]Sutnick AI,London WT,Gerstley BJ,et al.Anicteric hepatitisassociated with Australia antigen.Occurrence in patients withDown's syndrome[J].JAMA,1968,205(10):670-674.
- [5]Lander JJ,Giles JP,Purcell RH,et al.Viral hepatitis,type B(MS-2 strain).Detection of antibody after primary infection[J].N Engl J Med,1971,285(6):303-307.