术前肠内营养对老年乳腺癌患者围术期肠黏膜屏障功能、免疫功能和营养状况的影响Effect of preoperative enteral nutrition on intestinal mucosal barrier, immune function and nutritional status in elderly patients with breast cancer during perioperative period
周桔丰;苏小玉;王丹心;陈玲玲;何丽;
摘要(Abstract):
目的探究术前肠内营养对老年乳腺癌患者围术期肠黏膜屏障功能、免疫功能和营养状况的影响。方法将本院2014年8月至2017年10月收治的106例老年女性乳腺癌患者纳入本研究。采用随机数表法将入选患者分为观察组和对照组,每组各53例。两组患者术前均给予常规治疗和饮食干预,观察组患者在此基础上联合肠内营养支持治疗。比较两组患者干预前和术后7 d肠黏膜屏障功能、免疫功能和营养状况。结果观察组患者术后7 d血清降钙素原和D-乳酸水平均显著低于本组干预前和同期对照组(均P <0.05)。对照组患者术后7 d血清降钙素原和D-乳酸水平均显著高于本组干预前(均P <0.05),血清免疫球蛋白G、免疫球蛋白A、免疫球蛋白M、总蛋白、白蛋白水平和总淋巴细胞计数均显著低于本组干预前和同期观察组(均P <0.05)。观察组患者干预前和术后7 d免疫球蛋白G、免疫球蛋白A、免疫球蛋白M、血清总蛋白和白蛋白水平比较差异均无统计学意义(均P> 0.05)。两组患者干预前和术后7 d心理状态均无明显变化(均P> 0.05),且组间比较差异均无统计学意义(均P> 0.05)。结论术前肠内营养能够改善老年乳腺癌患者术后肠黏膜屏障功能,减轻手术创伤,改善应激所致免疫功能和营养状况变化,有望缩短患者住院天数、促进其早日康复,值得临床推广。
关键词(KeyWords): 肠内营养;乳腺癌;肠黏膜屏障;免疫功能;营养状况
基金项目(Foundation): 海南省卫生计生行业科研项目(16A200045)
作者(Authors): 周桔丰;苏小玉;王丹心;陈玲玲;何丽;
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