卢成志

• 1:天津市第一中心医院心血管病中心

摘要(Abstract)：

<正>前言高血压是最常见心血管疾病(CVD)和主要心血管疾病危险因素之一,发展中国家成人高血压发病率大约为30%～40%,且逐年增加[1]。尽管已经有多种不同机制的有效降压药物,仍有较高比例的高血压患者未能得到较好控制。多年前的研究已经发现交感神经系统在高血压的发生和发展过程中起重要作用。近年来,针对自主神经系统治疗顽

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation): 天津市卫生局科技重点攻关课题(10KG06)

作者(Author): 卢成志

参考文献(References)：

• [1]Kearney PM,Whelton M,Reynolds K,et al.Global burden of hypertension:analysis of worldwide data[J].Lancet,2005,365(9455):217-223.
• [2]Hering D,Lambert EA,Marusic P,et al.Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension[J].Hypertension,2013,61(2):457-464.
• [3]Krum H,Schlaich M,Whitbourn R,et al.Catheter-based renal sympathetic denervation for resistant hypertension:a multicentre safety and proof-of-principle cohort study[J].Lancet,2009,373(9671):1275-1281.
• [4]Esler MD,Krum H,Sobotka PA,et al.Renal sympathetic denervation in patients with treatment-resistant hypertension(The Symplicity HTN-2trial):a randomised controlled trial[J].Lancet,2010,376(9756):1903-1909.
• [5]Krum H,Barman N,Schlaich M,et al.Catheter-based renal sympathetic denervation for resistant hypertension:durability of blood pressure reduction out to24months[J].Hypertension,2011,57(5):911-917.
• [6]Esler MD,Krum H,Schlaich M,et al.Renal sympathetic denervation for treatment of drug-resistant hypertension:one-year results from the Symplicity HTN-2randomized,controlled trial[J].Circulation,2012,126(25):2976-2982.
• [7]Sobotka PA,Mahfoud F,Schlaich MP,et al.Sympatho-renal axis in chronic disease[J].Clin Res Cardiol,2011,100(12):1049-1057.
• [8]DiBona GF.Physiology in perspective:The Wisdom of the Body.Neural control of the kidney[J].Am J Physiol Regul Integr Comp Physiol,2005,289(3):R633-R641.
• [9]Esler M.The2009Carl Ludwig Lecture:Pathophysiology of the human sympathetic nervous system in cardiovascular diseases:the transition from mechanisms to medical management[J].J Appl Physiol,2010,108(2):227-237.
• [10]Bradford JR.The innervation of the renal blood vessels[J].J Physiol,1889,10(5):358-432.18.
• [11]Sobotka PA,Mahfoud F,Schlaich MP,et al.Sympatho-renal axis in chronic disease[J].Clin Res Cardiol,2011,100(12):1049-1057.
• [12]Smithwick RH.Surgical treatment of hypertension[J].Am J Med,1948,4(5):744-759.
• [13]Krum H,Schlaich M,Sobotka PA,et al.TCT-12long-term follow-up of catheter-based renal denervation for resistant hypertension confirms durable blood pressure reduction[J].J Am Coll Cardiol,2012,60:2012.08.017.
• [14]Mahfoud F,Cremers B,Janker J,et al.Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension[J].Hypertension,2012,60(6):419-424.
• [15]Hering D,Mahfoud F,Walton AS,et al.Renal denervation in moderate to severe CKD[J].J Am Soc Nephrol,2012,23(7):1250-1257..
• [16]Witkowski A,Prejbisz A,Florczak E,et al.Effects of renal sympathetic denervation on blood pressure,sleep apnea course,and glycemic control in patients with resistant hypertension and sleep apnea[J].Hypertension,2011,58(4):559-565.
• [17]Brandt MC,Mahfoud F,Reda S,et al.Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension[J].J Am Coll Cardiol,2012,59(10):901-909.
• [18]Davies JE,Manisty CH,Petraco R,et al.First-in-man safety evaluation of renal denervation for chronic systolic heart failure:Primary outcome from REACHPilot study[J].Int J Cardiol,2013,162(3):189-192.
• [19]Mahfoud F,Schlaich M,Kindermann I,et al.Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension:a pilot study[J].Circulation,2011,123(18):1940-1946.
• [20]Worthley SG,Tsioufis CP,Worthley MI,et al.Safety and effic-acy of a multi-electrode renal sympathetic denervation system in resistant hypertension:the EnligHTN I trial[J].Eur Heart J,2013[First published online:June19,2013].
• [21]Ormiston J,Watson T,van Pelt N,et al.First report of the 6-month first in human results of the OneShotTM renal denervation system:the RHAS study[J].J Am Coll Cardiol,2012,60(Suppl B):TCT-212.59.
• [22]Mabin T,Sapoval M,Cabane V,et al.First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension[J].EuroIntervention,2012,8(1):57-61.