王子文;高娟;赵小妹;李恳;齐凡星;刘国敏;殷树欣;刘理顺;黄晓;李建平;

• 1:承德医学院研究生学院
• 2:保定市第一中心医院神经内科
• 3:深圳市长卿医学研究院
• 4:南昌大学第二附属医院心血管内科

摘要(Abstract)：

大量研究表明,在普通人群中,即使血浆同型半胱氨酸水平适度升高,也可能促进动脉粥样硬化(atherosclerosis,AS)的发生和发展。5,10-亚甲基四氢叶酸还原酶(5,10-methylenetetrahydrofolate reductase,MTHFR)的基因结构改变使之催化活性减弱,间接导致高同型半胱氨酸血症。然而,MTHFR基因突变与AS导致的相关疾病的关系受多种环境因素的影响,从基因与环境交互作用这一新领域探索AS的发病机制成为近年来的热点话题。本文就MTHFR基因环境交互作用对AS及相关疾病的影响进行综述,旨在为预防因AS导致的缺血性疾病提供新思路。

关键词(KeyWords)： 亚甲基四氢叶酸还原酶;基因多态性;动脉粥样硬化;同型半胱氨酸;基因环境交互作用

Abstract:

Keywords:

基金项目(Foundation): 国家“十三五”战略性科技创新合作重点专项(2016YFE0205400)

作者(Authors): 王子文;高娟;赵小妹;李恳;齐凡星;刘国敏;殷树欣;刘理顺;黄晓;李建平;

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