陈国钦,区彩文,宋明才,张稳柱,李健豪,黄惠敏,梁伟杰,张在勇

• 1:广州市番禺区中心医院心内科
• 2:南方医科大学科技处

摘要(Abstract)：

目的评估老年冠心病患者经皮冠状动脉介入治疗(PCI)后联合使用质子泵抑制剂(PPI)及氯吡咯雷是否安全、有效。方法回顾本院PCI术后并有复查冠状动脉造影的老年患者(≥60岁),共317例,并根据联合使用PPI情况,分无PPI组(69例),PPI低暴露组(142例)及PPI高暴露组(106例),观察各组支架内再狭窄率及临床事件。结果平均随访时间为(14±6.5)个月,PPI高暴露组支架内再狭窄率比无PPI组显著增加(P<0.05),总的临床不良事件无显著性差异(P>0.05)。PPI低暴露组支架内再狭窄及心血管事件增加无显著性差异(P>0.05),出血事件明显减少(P<0.05)。结论对老年患者PCI术后长期使用PPI可增加支架内再狭窄及心血管风险,但总体是安全的,短期使用则更加安全有效。

关键词(KeyWords)： 冠心病;经皮冠状动脉介入治疗;质子泵抑制剂;氯吡咯雷;主要不良心脏事件

Abstract:

Keywords:

基金项目(Foundation): 广东省科技厅项目(2012B061700012);; 番禺区科技局项目(2011-Z-03-33)

作者(Author): 陈国钦,区彩文,宋明才,张稳柱,李健豪,黄惠敏,梁伟杰,张在勇

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