杨丹丹,白鸿远,马爱群

• 1:西安交通大学医学院第一附属医院心血管内科 教育部环境与疾病相关基因重点实验室/心血管离子通道病研究室 陕西省分子心脏病学重点实验室

摘要(Abstract)：

慢性心力衰竭时,心肌细胞离子流发生异常,细胞稳态调节作用激活,调节离子通道表达谱及其产物,引起多个离子通道电流的改变,从而恢复细胞内外离子流到理想水平,以维持心肌细胞的电稳定和平衡。稳态调节作用有利于心肌细胞的电稳定,大大提高了心肌细胞对环境的适应能力。但由于心肌细胞间稳态调节的不一致性,引起心肌电活动异常,从而导致心律失常的发生。因此在治疗慢性心力衰竭所致的心律失常时,应在减小心肌细胞工作负荷的同时尽可能地逆转离子通道谱的重构,以减少恶性心律失常的发生。本文主要对慢性心力衰竭的稳态调节作用、离子通道谱重构及导致心律失常的机制进行阐述,并简要介绍心律失常的治疗与展望。

关键词(KeyWords)： 慢性心力衰竭;离子通道谱;稳态调节;心律失常;治疗

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(30830051)

作者(Author): 杨丹丹,白鸿远,马爱群

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