孙婉璐,陈亚红

• 1:北京大学第三医院呼吸与危重症学科

摘要(Abstract)：

慢性阻塞性肺疾病(慢阻肺)和阻塞型睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是呼吸系统常见的具有临床异质性的两种疾病,二者同时存在为重叠综合征,具有不同的临床表型。OSAHS作为慢阻肺的合并症之一,对慢阻肺的病理生理变化、炎症、氧化应激、并发症及预后均有影响,但二者交互作用的发生机制尚不清楚。本文在流行病学基础上,对慢阻肺和OSAHS重叠交互作用的发生机制和影响进行综述,为临床提供参考。

关键词(KeyWords)： 慢性阻塞性肺疾病;阻塞型睡眠呼吸暂停低通气综合征;重叠综合征;临床表型;交互作用

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划-重大慢性非传染性疾病防控研究专项(2016YFC1304301);国家重点研发计划-精准医学研究重点专项和精准医学研究专项(2016YFC0903601,2016YFC0901102)

作者(Author): 孙婉璐,陈亚红

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