MicroRNAs参与血管内皮细胞衰老机制的研究进展
米雪楠,惠汝太,张伟丽
摘要(Abstract)：
血管内皮功能障碍是动脉粥样硬化形成和心血管事件发生的病理基础,越来越多的证据表明内皮细胞衰老参与血管功能紊乱的病理过程,因此血管内皮细胞衰老的调节机制成为国内外研究热点。微小RNA(MicroRNAs,miRNAs)是一类小的非编码RNA,能够调控组蛋白去乙酰化酶、细胞周期调节蛋白等基因的表达水平,继而调控血管内皮细胞的功能。本文主要综述了miRNAs参与内皮细胞衰老机制的研究进展。
关键词(KeyWords)： MicroRNAs;血管内皮细胞;衰老
基金项目(Foundation): 国家自然科学基金项目(81070172)
作者(Author): 米雪楠,惠汝太,张伟丽
参考文献(References)：
- [1]Hayashi T,Matsui-Hirai H,Miyazaki-Akita A,et al.Endothelial cellular senescence is inhibited by nitric oxide:implications in atherosclerosis associated with menopause and diabetes[J].Proc Natl Acad Sci USA,2006,103(45):17018-17023.
- [2]Suarez Y,Fernandez-Hernando C,Yu J,et al.Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis[J].Proc Natl Acad Sci USA,2008,105(37):14082-14087.
- [3]Altuvia Y,Landgraf P,Lithwick G,et al.Clustering and conservation patterns of human microRNAs[J].Nucleic Acids Res,2005,33(8):2697-2706.
- [4]Liu J,Valencia-Sanchez MA,Hannon GJ,et al.MicroRNA-dependent location of targeted mRNAs to mammalian P-bodies[J].Nat Cell Biol,2005,7(7):719-723.
- [5]Bartel DP.MicroRNAs:genomics,bio genesis,mechanism,and function[J].Cell,2004,116(2):281-297.
- [6]Hayflick L,Moorhead PS.The serial cultivation of human diploid cell strains[J].Exp Cell Res,1961,25:585-621.
- [7]Campisi J.Senescent cells,tumor suppression,and organismal aging:good citizens,bad neighbors[J].Cell,2005,120(4):513-522.
- [8]Sato I,Morita I,Kaji K,et al.Reduction of nitric oxide produ-cing activity associated with in vitro aging in cultured human umbilical vein endothelial cell[J].Biochem Biophys Res Commun,1993,195(12):1070-1076.
- [9]Matsushita H,Chang E,Glassford AJ,et al.eNOs activity is reduced in senescent human endothelial cells:Preservation by hTERT immortalization[J].Circ Res,2001,89(9):793-798.
- [10]Sato I,Kaji K,Morita I,et al.Augmentation of endothelin-1,prostacyclin and thromboxane A2secretion associated with in vitro ageing in cultured human umbilical vein endothelial cells[J].Mech Ageing Dev,1993,71(1-2):73-84.
- [11]Comi P,Chiaramonte R,Maier JA.Senescence-dependent regulation of type1plasminogen activator inhibitor in human vascular endothelial cells[J].Exp Cell Res,1995,219(1):304-308.
- [12]Ito T,Yagi S,Yamakuchi M.MicroRNA-34a regulation of endothelial senescence[J].Biochem Biophys Res Commun,2010,398(4):735-740.
- [13]Haigis MC,Guarente LP.Mammalian sirtuins–emerging roles in physiology,aging,and calorie restriction[J].Genes Dev,2006,20(21):2913-2921.
- [14]Zhao T,Li J,Chen AF.MicroRNA34a induces endothelial-progenitor cell senescence and impedes its angiogenesis via suppressing silentinformation regulator1[J].Am J Physiol Endocrinol Metab,2010,299(1):E110-E116.
- [15]Menghini R,Casagrande V,Cardellini M,et al.MicroRNA217modulates endothelial cell senescence via silent information regulator1[J].Circulation,2009,120(15):1524-1532.
- [16]Brunet A,Sweeney LB,Sturgill JF,et al.Stress-dependent regulation of FOXO transcription factors by the SIRT1deacetylase[J].Science,2004,303(5666):2011-2015.
- [17]Magenta A,Cencioni C,Fasanaro P,et al.miR-200c is upre-gulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1inhibition[J].Cell Death Differ,2011,18(10):1628-1639.
- [18]Guzik TJ,Sadowski J,Guzik B.Coronary artery superoxide production and nox isoform expression in human coronary artery disease[J].Arterioscler Thromb Vasc Biol,2006,26(2):333-339.
- [19]Vasa-Nicotera M,Chen H,Tucci P,et al.miR-146a is modulated in human endothelial cell with aging[J].Atherosclerosis,2011,217(2):326-330.