• 1:中华医学会糖尿病学分会

摘要(Abstract)：

<正>1背景血糖监测是糖尿病管理中的重要组成部分,血糖监测的结果有助于评估糖尿病患者糖代谢紊乱的程度,制定降糖方案,同时反映降糖治疗的效果并指导对治疗方案的调整[1]。患者进行自我血糖监测(SMBG)是血糖监测的基本形式,而糖化血红蛋白(HbA1c)是反映长期血糖控制水平的金标准。但无论是HbA1c还是SMBG,自身都存在一定的局限性。HbA1c反映的是过去2～3个月的平均

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author):

参考文献(References)：

• [1]中华医学会糖尿病学分会.中国血糖监测临床应用指南(2011年版)[J].中华糖尿病杂志,2011,3:13-21.
• [2]中华医学会糖尿病学分会.中国动态血糖监测临床应用指南(2009年版)[J].中华医学杂志,2009,89:3388-3392.
• [3]Blevins TC,Bode BW,Garg SK,et al.AACF Continuous Glucose Monitoring Task Force.Statement by the American Association of Clinical Endocrinologists consensus panel on continuousglucosemonitoring[J].EndocrPract,2010,16:730-745.
• [4]Klonoff DC,Buokinsham B,Christiansen.JS,et al.Continuous glucose monitoring:an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2011,96:2968-2979.
• [5]Ginsberg BH.The FDApanel advises approval of the first continuous glucosesensor[J].DiabetesTechnolTher,1999,1:203-204.
• [6]贾伟平.信息改变认知:动态血糖监测在临床中的应用[J].中华医学杂志,2009,89:649-650.
• [7]Wentholt IM,Hart AA,Hoekstra JB,et al.How to assess and compare the accuracy of continuous glucose monitors?[J].Diabetes Technol Ther,2008,10:57-68.
• [8]冉兴无.动态血糖监测系统的准确性评估[J].中华糖尿病杂志,2011,3:196-200.
• [9]吕丽芳,王椿,杨阎峙,等.动态血糖监测系统的准确性和安全性分析[J].中华医学杂志,2010,90:2967-2970.
• [10]Zhou J,Lv X,Mu Y,et al.The accuracy and efficacy of real-time continuous glucose monitoring sensor in Chinese diabetes patients:a multicenter study[J].Diabetes Technol Ther,2012,14:710-718.
• [11]李强,王莹莹,于萍,等.实时动态血糖监测与静脉血糖、毛细血管血糖检测的相关性[J].中华医学杂志,2010,90:2971-2975.
• [12]王莹莹,李强,于萍,等.实时动态血糖监测系统在不同时段检测的准确性变化特征及其与血糖波动的关系[J].中华内分泌代谢杂志,2011,27:224-228.
• [13]郎江明,陈苹,魏爱生,等.新诊断2型糖尿病患者24小时血糖的波动特点[J].中华糖尿病杂志,2005,13:43-45.
• [14]喻明,周健,项坤三,等.动态监测新诊断2型糖尿病患者的血糖水平[J].中华糖尿病杂志,2005,13:102-104.
• [15]周健,贾伟平,喻明,等.上海地区中国人餐后血糖状态的特征[J].中华医学杂志,2006,86:970-975.
• [16]魏爱生,王甫能,陈苹,等.甘精胰岛素联合格列美脲及阿卡波糖治疗2型糖尿病患者24小时动态血糖变化[J].中华内分泌代谢杂志,2006,22:325-326.
• [17]Bao YQ,Zhou J,Zhou M,et al.Glipizide controlled-release tablets with or without acarbose improves glycemic variability in newly diagnosed type2diabetes[J].Clin Exp Pharmacol Physiol,2010,37:564-568.
• [18]康怡,陆菊明,张丹丹,等.应用动态血糖监测系统评价格列喹酮对新发2型糖尿病血糖波动的控制及其促泌作用[J].中华糖尿病杂志,2012,4:95-100.
• [19]李晓静,高政南,程丽静,等.采用CGMS评价阿卡波糖对胰岛素治疗血糖波动的影响[J].中华内分泌代谢杂志,2012,28:140-143.
• [20]王先令,陆菊明.血糖波动对糖尿病预后及其慢性并发症发生发展的影响[J].国外医学内分泌分册,2005,25:169-171.
• [21]贾伟平.血糖波动与靶器官损害[J].中华医学杂志,2006,86:2524-2525.
• [22]周健,贾伟平,马晓静,等.糖化血红蛋白控制理想的2型糖尿病患者血糖波动的特征及其与微量白蛋白尿的关系[J].中华医学杂志,2008,88:2977-2981.
• [23]康怡,陆菊明,孙敬芳,等.不同糖调节受损人群的血糖波动特征[J].中华医学杂志,2009,89:669-674.
• [24]周健,李红,杨文英,等.正常糖调节人群早期相胰岛素分泌与血糖波动的关系[J].中华糖尿病杂志,2009,1:89-93.
• [25]Chen XM,Zhang Y,Shen XP,et al.Correlation between glucose fluctuations and carotid intima-media thickness in type2diabetes[J].Diabetes Res Clin Pract,2010,90:95-99.
• [26]Ma CM,Yin FZ,Wang R,et al.Glycemic variability in abdominally obese men with normal glucose tolerance as assessed by continuous glucose monitoring system[J].Obesity(Silver Spring),2011,19:1616-1622.
• [27]Su JB,Wang XQ,Chen JF,et al.Glycemic variability in insulin treated type2diabetes with well-controlled hemoglobin A1c and its response to farther treatment with acarbose[J].Chin Med J(Engl),2011,124:144-147.
• [28]Wang Z,Li L,Zheng F,et al.Correlation between the amplitude of glucose excursion and the oxidative/antioxidative system in subjects with different types of glucose regulation[J].Biomed Environ Sci,2011,24:68-73.
• [29]Sun J,Dou JT,Wang XL,et al.Correlation between1,5-anhydroglucitol and glycemic excursions in type2diabetic patients[J].Chin Med J(Engl),2011,124:3641-3645.
• [30]Su JB,Wang XQ,Chen JF,et al.Glycemic variability in gestational diabetes mellitus and its association with beta cell function[J].Endocrine,2012,Jul20.
• [31]Zhong Y,Zhang XY,Miao Y,et al.The relationship between glucose excursion and cognitive function in aged type2diabetes patients[J].Biomed Environ Sci,2012,25:1-7.
• [32]Mi SH,Su G,Li Z,et al.Comparison of glycemic variability and glycated hemoglobin as risk factors of coronary artery disease in patients with undiagnosed diabetes[J].Chin Med J(Engl),2012,125:38-43.
• [33]Wang Y,Zhang YL,Wang YP,et al.A study on the association of serum1,5-anhydroglucitol levels and the hyperglycaemic excursions as measured by continuous glucose monitories system among people with type2diabetes in China[J].Diabetes Metab Res Rev,2012,28:357-362.
• [34]Wang C,Lv L,Yang Y,et al.Glucose fluctuations in subjects with normal glucose tolerance,impaired glucose regulation and newly diagnosed type2diabetes mellitus[J].Clin Endocrinol(Oxf),2012,76:810-815.
• [35]周健,贾伟平.血糖稳定性的意义及临床评估[J].中华医学杂志,2006,86:2154-2157.
• [36]李强,李鹏杰.血糖波动的意义及临床评价方法[J].中国实用内科杂志,2009,29:876-878.
• [37]Service FJ,Molnar GD,Rosevear JW,et al.Mean amplitude of glycemic excursions,a measure of diabetic instability[J].Diabetes,1970,19:644-655.
• [38]Monnier L,Mas E,Ginet C,et al.Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type2diabetes[J].JAMA,2006,295:1681-1687.
• [39]周健,喻明,贾伟平,等.应用动态血糖监测系统评估2型糖尿病患者日内及日间血糖波动幅度[J].中华内分泌代谢杂志,2006,22:286-288.
• [40]康怡,陆菊明,吕朝辉,等.不同糖调节人群血糖波动与氧化应激的相关性分析[J].中华糖尿病杂志,2009,1:19-24.
• [41]卞华,高鑫,高键.住院糖尿病患者β细胞功能损伤与血糖波动的关系[J].中华医学杂志,2009,89:664-668.
• [42]Zheng F,Lu W,Jia C,et al.Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type2diabetes or impaired glucose regulation[J].Endocrine,2010,37:201-208.
• [43]吴国富,麦一峰,罗薇,等.动态血糖监测探讨2型糖尿病患者睡前血糖和夜间低血糖的关系[J].中华内分泌代谢杂志,2006,22:323-324.
• [44]李鸣,周健,包玉倩,等.睡前血糖预测2型糖尿病患者胰岛素泵治疗期间夜间低血糖的发生[J].中华医学杂志,2010,90:2962-2966.
• [45]王砚,关守萍,康莹,等.应用动态血糖监测评估2型糖尿病患者的夜间低血糖[J].中华内分泌代谢杂志,2010,26:393-394.
• [46]周琳,吴静,薛耀明.妊娠期糖尿病患者餐后血糖的波动特点[J].实用医学杂志,2006,22:2250-2251.
• [47]袁涛,赵维纲,付勇,等.动态血糖监测系统在妊娠期糖代谢异常患者中的应用[J].中华临床营养杂志,2010,18:80-83.
• [48]WangXL,LuJM,PanCY,etal.Evaluationofthesuperiorityofinsulin glargineasbasalinsulinreplacementbycontinuousglucosemonitoring system[J].DiabetesResClinPract,2007,76:30-36.
• [49]李焱,梁骏,梁颖,等.三种胰岛素强化治疗方案的短期疗效和安全性比较[J].中华内分泌代谢杂志,2008,24:620-622.
• [50]罗兰,高政南,卢林娜,等.应用动态血糖监测及高胰岛素-正糖钳夹技术评价地特胰岛素对2型糖尿病患者的疗效及安全性[J].中华糖尿病杂志,2011,3:215-218.
• [51]曾文衡,何晓雯,沈洁,等.2型糖尿病合并胃轻瘫患者的动态血糖谱[J].中华内科杂志,2008,47:347-400.
• [52]周健,包玉倩,李鸣,等.暴发性1型糖尿病的临床特征及治疗策略探讨[J].中华糖尿病杂志,2009,1:34-38.
• [53]陆蔚,周健,贾伟平,等.类固醇糖尿病患者动态血糖谱的特点及临床意义[J].上海交通大学学报(医学版),2007,27:788-790.
• [54]周健,贾伟平,包玉倩,等.胰岛素瘤患者动态血糖谱的特点及意义[J].上海交通大学学报(医学版),2007,27:781-784.
• [55]Huang Z,Li Y,Tang T,et al.Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulinreceptor(IR)gene[J].ClinEnrlocrinol,2009,71:659-665.
• [56]Tao M,Zhou J,Zhu J,et al.Continuous glucose monitoring reveals abnormal features of postprandial glycemic excursions in women with polycystic ovarian syndrome[J].Postgrad Med,2011,123:185-190.
• [57]Bian H,Yan H,Zeng M,et al.Increased liver fat content and unfavorable glucose profiles in subjects without diabetes[J].Diabetes Technol Ther,2011,13:149-155.
• [58]Su G,Mi S,Tao H,et al.Association of glycemic variability and thepresenceandseverityofcoronaryarterydiseaseinpatientswith type2diabetes[J].CardiovascDiabetol,2011,10:19.
• [59]陈莉丽,李强,王薇,等.应用持续血糖监测系统评估2型糖尿病患者一级亲属的糖代谢状态[J].中华医学杂志,2009,89:655-658.
• [60]徐扬,周健,姚海军,等.神经外科重症患者的动态血糖监测[J].中华神经外科杂志,2010,26:543-546.
• [61]方芳,赵咏桔.动态血糖仪的工作原理和误差评估[J].国际内分泌代谢杂志,2007,27:169-171.
• [62]王先令,陆菊明,潘长玉.动态血糖监测系统的临床应用[J].军医进修学院学报,2005,26:63-65.
• [63]黄晨,李榕,徐先桔,等.持续性血糖监测系统临床应用的可靠性研究[J].中国实用内科杂志,2006,26:37-38.
• [64]喻明,周健,项坤三,等.动态监测糖耐量正常者血糖水平的漂移变化[J].中华医学杂志,2004,84:1788-1790.
• [65]周健,贾伟平,喻明,等.动态血糖参数正常参考值的建立和临床应用[J].中华内科杂志,2007,46:189-192.
• [66]何利平,王椿,钟莉,等.成都地区糖耐量正常者血糖水平变化的特征分析[J].四川大学学报(医学版),2009,40:704-707.
• [67]Zhou J,Li H,Ran X,et al.Reference values for continuous glucose monitoring in Chinese subjects[J].Diabetes Care,2009,32:1188-1193.
• [68]Zhou J,Li H,Ran X,et al.Establishment of normal reference ranges glycemic variability in Chinese subjects using continuous monitories[J].Med Sci Monit,2011,17:CR9-13.
• [69]陆蔚,周健,包玉倩,等.动态血糖监测系统的临床应用及故障原因分析[J].中华护理杂志,2008,43:561-562.
• [70]郑晓萍,邵莹,邹朝春.动态血糖监测系统在儿童1型糖尿病中的应用和护理[J].中华护理杂志,2008,43:235-236.
• [71]陆蔚,周健,包玉倩,等.2例幼儿糖尿病患者动态血糖监测的护理[J].中华护理杂志,2009,44:713-714.
• [72]Juvenile Diabetes Research Foundation Continuous Glucose MonitoringStudyGroup.Continuousglucosemonitoringandintensive treatmentoftype1diabetes[J].NEnglJMed,2008,359:1464-1476.
• [73]Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group.The effect of continuous glucose monitoring in well-controlled type1diabetes[J].Diabetes Care,2009,32:1378-1383.