中国脑卒中一级预防研究的意义与进展
霍勇,秦献辉,张岩,徐希平
摘要(Abstract):
<正>1前言近期Lancet杂志发表的荟萃分析包括了273项全球基因研究数据库[具有同型半胱氨酸(homocysteine,Hcy)值的患者59995例、卒中事件20885例]和13项降低Hcy与脑卒中风险的随机临床试验数据库[45549例,卒中事件2314例,短暂性脑缺血(transient ischemic attack,TIA)269例][1]。荟萃分析结果表明
关键词(KeyWords):
基金项目(Foundation): 国家十二五·重大新药创制专项(2012ZX09101105)
作者(Author): 霍勇,秦献辉,张岩,徐希平
参考文献(References):
- [1]Holmes MV,Newcombe P,Hubacek JA,et al.Effect modification by population dietary folate on the association between MTHFR genotype,homocysteine,and stroke risk:a meta-analysis of genetic studies and randomised trials[J].Lancet,2011,378(9791):584-594.
- [2]胡盛寿,孔灵芝.中国心血管病报告[M].北京:中国大百科全书出版社,2006:11.
- [3]Zhao D,Liu J,Wang W,et al.Epidemiological transition of stroke in China:twenty-one-year observational study from the Sino-MONICA-Beijing Project[J].Stroke,2008,39(6):1668-1674.
- [4]Wald NJ,Law MR.A strategy to reduce cardiovascular disease by more than80%[J].BMJ,2003,326(7404):1419.
- [5]Lonn E,Yusuf S,Arnold MJ,et al.Homocysteine lowering with folic acid and B vitamins in vascular disease[J].N Engl J Med,2006,354(15):1567-1577.
- [6]李建平,霍勇,刘平,等.马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J].北京大学学报(医学版),2007,39(6):614-618.
- [7]Wald D S,Law M,Morris JK.Homocysteine and cardiova-scular disease:evidence on causality from a metaa nalysis[J].BMJ,2002;325(7374):1202.
- [8]Cui HC,Wang F,Fan L,et al.Association factors of target organ damage:analysis of17682elderly hypertensive patients in China[J].Chin Med J,2011,124(22):3676-3681.
- [9]Graham IM,Daly LE,Refsum HM,et al.Plasma homocysteine as a risk factor for vascular disease.The European Concerted Action Project[J].JAMA,1997,277(22):1775-1781.
- [10]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中国医学前沿杂志(电子版),2011,5(3):42-93.
- [11]胡大一,徐希平.有效控制“H型”高血压——预防卒中的新思路[J].中华内科杂志,2008,47(12):976-977.
- [12]王拥军,刘力生,饶克勤,等.我国脑卒中预防策略思考:同时控制高血压和高同型半胱氨酸水平[J].中华医学杂志,2008,88(47):3316-3318.
- [13]郝玲,郑俊池,田熠华,等.血浆叶酸两种常用方法检测结果的比较[J].北京大学学报(医学版),2004,36(2):210-214.
- [14]Yang Q,Botto LD,Erickson D,et al.Improvement in stroke mortality in Canada and the United States,1990to2002[J].Circulation,2006,113(10):1335-1343.
- [15]Qin X,Xu M,Zhang Y,et al.Effect of Folic Acid Supplemen-tation on the Progression of Carotid Intima-Media Thickness:A Meta-Analysis of Randomized Controlled Trials[J].Atherosclerosis,2012,222(2):307-313.
- [16]Mark SD,Wang W,Fraumeni JF Jr,et al.Lowered Risks of Hypertension and Cerebrovascular Disease after Vitamin/Mineral Supplementation:the Linxian Nutrition Intervention[J].Am J Epidemiol,1996,143(7):658-664.
- [17]Lonn E,Yusuf S,Arnold MJ,et al.Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease[J].N Engl J Med,2006,354(15):1567-1577.
- [18]Wang X,Qin X,Demirtas H,et al.Efficacy of folic acid supplementation in stroke prevention:a meta-analysis[J].Lancet,2007,369(9576):1876-1882.
- [19]Qin X,Cui Y,Shen L,et al.Folic acid supplementation and cancer risk:A meta-analysis of randomized controlled trials[J].Int J Cancer,2013.
- [20]Vollset SE,Clark R,Lewington S,et al.Effects of folic acid supplementation on overall and site-specific cancer incidence during randomised trials:meta-analyses of data on50000individuals[J].Lancet,2013.
- [21]Durga J,van Boxtel MP,Schouten EG,et al.Effect of3-year folic acid supplementation on cognitive function in older adults in the FACIT trial:a randomised,double blind,controlled trial[J].Lancet,2007,369(9557):208-216.
- [22]van Vark LC,Bertrand M,Akkerhuis KM,et al.Angiotensin-converting enzyme inhibitors reduce mortality in hypertension:a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving158,998patients[J].Eur Heart J,2012,33(16):2088-2097.
- [23]Albert CM,Cook NR,Gaziano JM,et al.Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease:a randomized trial[J].JAMA,2008,299(17):2027-2036.