乙型肝炎表面抗原在自然病程中的变化与临床意义
高嘉宏
摘要(Abstract):
<正>全世界约有3.5亿乙型肝炎表面抗原携带者,其中0.6亿人最终可能死于肝癌,而0.45亿人最终可能死于肝硬化。据估计每年约有100万人死于慢性乙型肝炎及其并发症。台湾自从民国73年开始施行新生儿乙型肝炎疫苗注射后,成果良好,学龄前儿童之带原率已由疫苗接种前的10%,大幅降低到目前的<1%,同时儿童肝癌的年发生率亦有显著下降。但在成年人之中仍有5%~20%是乙
关键词(KeyWords):
基金项目(Foundation):
作者(Author): 高嘉宏
参考文献(References):
- [1]Blumberg BS,Sutnick AI,London WT.Hepatitis and leukemia:their relation to Australia antigen[J].Bull NY Acad Med,1968,44(12):1566-1586.
- [2]Kao JH,Chen PJ,Chen DS.Recent advances in the researchof hepatitis B virus-related hepatocellular carcinoma:epidemiologic and molecular biological aspects[J].Adv CancerRes,2010,108:21-72.
- [3]Kao JH,Chen DS.Global control of hepatitis B virusinfection[J].Lancet Infect Dis,2002,2(7):395-403.
- [4]Tseng TC,Liu CJ,Su TH,et al.Serum hepatitis B surfaceantigen levels predict surface antigen loss in hepatitis B eantigen seroconverters[J].Gastroenterology,2011,141(2):517-525 e2.
- [5]Tseng TC,Kao JH.Clinical utility of quantitative HBsAg innatural history and nucleos(t)ide analogue treatment of chronichepatitis B:new trick of old dog[J].J Gastroenterol,2013,48(1):13-21.
- [6]Tseng TC,Liu CJ,Chen CL,et al.Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes inspontaneous hepatitis B e antigen seroconverters[J].J InfectDis,2012(1),205:54-63.
- [7]Chan HL,Wong VW,Wong GL,et al.A longitudinal study onthe natural history of serum hepatitis B surface antigen changesin chronic hepatitis B[J].Hepatology,2010,52(4):1232-1241.
- [8]Tseng TC,Liu CJ,Yang HC,et al.Determinants of spontaneoussurface antigen loss in hepatitis B e antigen-negative patientswith a low viral load[J].Hepatology,2012,55(1):68-76.
- [9]Tseng TC,Liu CJ,Yang HC,et al.High levels of hepatitisB surface antigen increase risk of hepatocellular carcinomain patients with low HBV load[J].Gastroenterology,2012,142(5):1140-1149 e3.
- [10]Tseng TC,Liu CJ,Yang HC,et al.Serum hepatitis B surfaceantigen levels help predict disease progression in patients withlow HBV loads[J].Hepatology,2013,57(2):441-450.
- [11]Tseng TC,Kao JH.Clinical utility of quantitative HBsAg innatural history and nucleos(t)ide analogue treatment of chronichepatitis B:new trick of old dog[J].J Gastroenterol,2013,48(1):13-21.
- [12]Tseng TC,Liu CJ,Chen CL,et al.Risk stratification ofhepatocellular carcinoma in hepatitis B virus e antigen-negativecarriers by combining viral biomarkers[J].J Infect Dis,2013,208(4):584-593.