3.0T磁共振弥散张量成像联合三维动脉自旋标记在新生儿缺氧缺血性脑病中的应用价值Application value of 3.0T magnetic resonance diffusion tensor imaging combined with three-dimensional arterial spin labeling in neonatal hypoxic ischemic encephalopathy
刘蓉;郑娜;
摘要(Abstract):
目的探究3.0T磁共振弥散张量成像(diffusion tensor imaging,DTI)联合三维动脉自旋标记(arterial spin labeling,ASL)对诊断新生儿缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)和评估病情严重程度的应用价值。方法选取榆林市第二医院2014年9月至2018年9月收治的118例足月HIE新生儿纳入HIE组,选取同期45例无神经系统疾病的足月新生儿纳入对照组。两组新生儿均接受DTI联合ASL横轴位序列扫描,比较各感兴趣区DTI参数值、相对脑血流量,并分析DTI、ASL分度与临床分度的一致性。结果 HIE组患儿基底节部分各向异性(fractional anisotropy,FA)、相对各向异性(relative anisotropy,RA)均低于对照组,容积再现(volume rendering,VR)高于对照组,差异均有统计学意义(均P <0.05)。HIE组患儿基底节和丘脑相对脑血流量多于对照组,且随着病情加重其相对脑血流量逐渐增多,差异均有统计学意义(均P <0.05)。基底节FA、基底节和丘脑相对脑血流量评估HIE病情分度与临床评估结果比较差异均无统计学意义(均P> 0.05)。结论 3.0T磁共振DTI联合ASL能够为新生儿HIE的诊断和病情评估提供可靠参考。
关键词(KeyWords): 磁共振;弥散张量成像;动脉自旋标记;新生儿;缺氧缺血性脑病
基金项目(Foundation): 陕西省科学技术发展计划研究项目(2014K11-05-05)
作者(Authors): 刘蓉;郑娜;
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