血清1,25-(OH)_2D_3、IL-17、IL-35及MMP-9水平与哮喘急性发作期患儿病情严重程度的相关性研究Correlation between serum levels of 1,25-(OH)_2D_3,IL-17,IL-35,MMP-9 and disease severity in children with acute exacerbation of asthma
卫文峰;杨明珠;
摘要(Abstract):
目的探讨血清1,25-二羟基维生素D_3[1,25-(OH)_2D_3]、白介素(interleukin,IL)-17、IL-35及基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平与哮喘急性发作期患儿病情严重程度的相关性。方法选取2016年1月至2018年1月本院收治的285例哮喘急性发作期患儿为研究对象,根据病情严重程度将其分为轻度组(77例)、中度组(119例)和重度组(89例),并选取同期于本院体检的80例健康儿童纳入对照组。比较各组儿童血清1,25-(OH)_2D_3、IL-17、IL-35与MMP-9水平。结果四组儿童的血清1,25-(OH)_2D_3、IL-17、IL-35及MMP-9水平比较差异均有显著性(P_均<0.05),且两两比较均有显著差异(P_均<0.05);血清1,25-(OH)_2D_3和IL-35水平:对照组>轻度组>中度组>重度组;血清MMP-9和IL-17水平:对照组<轻度组<中度组<重度组。结论哮喘急性发作期患儿的血清1,25-(OH)_2D_3和IL-35水平显著降低,MMP-9和IL-17水平显著升高,与疾病严重程度有关,具有潜在的临床价值。
关键词(KeyWords): 哮喘;1,25-二羟基维生素D_3;基质金属蛋白酶-9;白介素-17;白介素-35
基金项目(Foundation): 陕西省科学技术研究发展计划项目(2012K16-08)
作者(Authors): 卫文峰;杨明珠;
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