1型糖尿病细胞治疗研究进展
肖潇雨,李霞,周智广
摘要(Abstract):
<正>1概述1型糖尿病(type 1 diabetes mellitus,T1DM)以β细胞永久性破坏为特征,病因迄今尚未阐明,但自身免疫异常是其最主要的致病因素。胰岛素是T1DM治疗的支柱,临床试验已表明强化胰岛素治疗可以降低相关血管并发症的风险[1]。然而,对大多数患者而言,胰岛素治疗不仅无法将患者血糖水
关键词(KeyWords):
基金项目(Foundation): 国家自然科学基金(81170725);; 欧洲糖尿病研究基金(EFSD/CDS/Lilly-2010);; 教育部长江学者和创新团队发展计划资助(IRT1195)
作者(Author): 肖潇雨,李霞,周智广
参考文献(References):
- [1]The Diabetes Control and Complications Trial Research Group.The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus[J].N Engl J Med,1993,329(14):977-986.
- [2]Gruessner RW,Gruessner AC.The current state of pancreas transplantation[J].Nat Rev Endocrinol,2013,9(9):555-562.
- [3]Zinger A,Leibowitz G.Islet transplantation in type 1 diabetes:hype,hope and reality-a clinician's perspective[J].Diabetes Metab Res Rev,2013[Epub ahead of print].
- [4]Agarwal A,Brayman KL.Update on islet cell transplantation for type 1 diabetes[J].Semin Intervent Radiol,2012,29(2):90-98.
- [5]Rezania A,Bruin JE,Riedel MJ,et al.Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treatingpre-existing diabetes in mice[J].Diabetes,2012,61(8):2016-2029.
- [6]Xiao X,Chen Z,Shiota C,et al.No evidence forβcell neogenesis in murine adult pancreas[J].J Clin Invest,2013,123(5):2207-2217.
- [7]Cavelti-Weder C,Shtessel M,Reuss JE,et al.Pancreatic duct ligation after almost complete beta-cell loss:Exocrine regeneration but no evidence of beta-cell regeneration[J].Endocrinology,2013[Epub ahead of print].
- [8]Xu X,D'Hoker J,StangéG,et al.Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas[J].Cell,2008,132(2):197-207.
- [9]Hao E,Lee SH,Levine F.Efficientβ-cell regeneration by a combination of neogenesis and replication followingβ-cell ablation and reversal of pancreatic duct ligation[J].Stem Cells,2013[Epub ahead of print].
- [10]Ren B,O'Brien BA,Byrne MR,et al.Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy[J].J Gene Med,2013,15(1):28-41.
- [11]Tang DQ,Shun L,Koya V,et al.Genetically reprogrammed,liver-derived insulin-producing cells are glucose-responsive,but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes[J].Am J Transl Res,2013,5(2):184-199.
- [12]Montanucci P,Pennoni I,Pescara T,et al.Treatment of diabetes mellitus with microencapsulated fetal human liver(FH-B-TPN)engineered cells[J].Biomaterials,2013,34(16):4002-4012.
- [13]Lim JJ,Kim HJ,Kim KS,et al.In vitro culture-induced pluripotency of human spermatogonial stem cells[J].Biomed Res Int,2013,2013:143028.
- [14]Chikhovskaya JV,Jonker MJ,Meissner A,et al.Human testisderived embryonic stem cell-like cells are not pluripotent,but possess potential of mesenchymal progenitors[J].Hum Reprod,2012,27:210-221.
- [15]Mabed M,Shahin M.Mesenchymal stem cell-based therapy for the treatment of type 1 diabetes mellitus[J].Curr Stem Cell Res Ther,2012,7:179-190.
- [16]De Miguel MP,Fuentes-Julián S,Blázquez-Martínez A,et al.Immunosuppressive properties of mesenchymal stem cells:advances and applications[J].Curr Mol Med,2012,12:574-591.
- [17]Mundra V,Gerling IC,Mahato RI.Mesenchymal stem cellbased therapy[J].Mol Pharm,2013,10:77-89.
- [18]Kerby A,Jones ES,Jones PM,et al.Co-transplantation of islets with mesenchymal stem cells in microcapsules demonstrates graft outcome can be improved in an isolated-graft model of islet transplantation in mice[J].Cytotherapy,2013,15(2):192-200.
- [19]Rackham CL,Dhadda PK,Chagastelles PC,et al.Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice[J].Cytotherapy,2013,15(4):449-459.
- [20]Karaoz E,Okcu A,ünal ZS,et al.Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulinproducing cells in pancreatic islet microenvironment both in vitro and in vivo[J].Cytotherapy,2013,15(5):557-570.
- [21]Li L,Shen S,Ouyang J,et al.Autologous hematopoietic stem cell transplantation modulates immunocompetent cells and improvesβ-cell function in Chinese patients with new onset of type 1 diabetes[J].J Clin Endocrinol Metab,2012,97(5):1729-1736.
- [22]Gu W,Hu J,Wang W,et al.Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes[J].Diabetes Care,2012,35(7):1413-1419.
- [23]Dave SD,Trivedi HL,Chooramani SG,et al.Management of type 1 diabetes mellitus using in vitro autologous adipose tissue trans-differentiated insulin-making cells[J].BMJ Case Rep,2013[Epub ahead of print].
- [24]Okano H,Nakamura M,Yoshida K,et al.Steps toward safe cell therapy using induced pluripotent stem cells[J].Circ Res,2013,112(3):523-533.
- [25]Kudva YC,Ohmine S,Greder LV,et al.Transgene-free diseasespecific induced pluripotent stem cells from patients with type 1and type 2 diabetes[J].Stem Cells Transl Med,2012,1(6):451-461.
- [26]Kikodze N,Pantsulaia I,Rekhviashvili Kh,et al.Cytokines and T regulatory cells in the pathogenesis of type 1 diabetes[J].Georgian Med News,2013,(222):29-35.
- [27]Marek-Trzonkowska N,Mysliwiec M,Dobyszuk A,et al.Administration of CD4+CD25highCD127-regulatory T cells preservesβ-cell function in type 1 diabetes in children[J].Diabetes Care,2012,35(9):1817-1820.
- [28]Thompson JA,Perry D,Brusko TM.Autologous regulatory T cells for the treatment of type 1 diabetes[J].Curr Diab Rep,2012,12(5):623-632.
- [29]Bettini ML,Pan F,Bettini M,et al.Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency[J].Immunity,2012,36(5):717-730.
- [30]Giannoukakis N,Phillips B,Finegold D,et al.Phase I(safety)study of autologous tolerogenic dendritic cells in type 1 diabetic patients[J].Diabetes Care,2011,34(9):2026-2032.
- [31]Zhao Y,Wang H,Mazzone T.Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics[J].Exp Cell Res,2006,312(13):2454-2464.
- [32]Zhao Y,Jiang Z,Zhao T,et al.Reversal of type 1 diabetes via isletβcell regeneration following immune modulation by cord blood-derived multipotent stem cells[J].BMC Med,2012,10:3.