高智玉,王维宝

• 1:山东省淄博市淄川区医院神经内科

摘要(Abstract)：

目的探讨慢性焦虑、抑郁障碍与血糖、血脂及血浆纤维蛋白原(Fg)水平的相互关系,进而为了解精神因素与躯体疾病之间的精神生物学机制提供线索。方法按照DMS-Ⅳ标准,对本院神经科于2012年12月至2013年4月间新入院的患者,由同一位有经验的精神科临床医师对他们进行入院前20~30年或更长时期以来的精神状态包括焦虑和抑郁两个方面进行严重程度评分,同时采集患者入院当日或次日血样,化验检测其空腹血糖、血脂及血浆Fg水平,然后进行统计分析,了解患者慢性焦虑、抑郁评分与其当前血糖、血脂及血浆Fg水平之间的关系。结果统计分析显示,焦虑障碍评分与血糖、血脂各指标之间无显著相关性(P>0.05),与血浆Fg水平之间呈显著负相关(P<0.01);抑郁障碍评分与血糖、血脂各指标及血浆Fg水平之间均未显示有显著相关性(P>0.05)。有焦虑组与无焦虑组做比较,有焦虑组血浆Fg水平明显低于无焦虑组(P<0.01)。有焦虑组血糖水平低于无焦虑组,但无显著差异(P=0.094)。结论慢性焦虑有降低血浆Fg水平的作用,从而对血栓形成性疾病如脑梗死、冠心病等可能有保护作用。

关键词(KeyWords)： 焦虑和抑郁评分;血糖;血脂;血浆纤维蛋白原

Abstract:

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基金项目(Foundation):

作者(Author): 高智玉,王维宝

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