马赛,曹丰

• 1:第四军医大学西京医院心脏内科

摘要(Abstract)：

SIRT1是酵母菌沉默信息调节因子2的同源基因,其主要通过对组蛋白及多种非组蛋白发挥去乙酰化作用,参与调节糖脂代谢、细胞周期调控、抑制炎症及氧化应激损伤等生理病理过程,与许多心血管疾病如动脉粥样硬化、糖尿病心肌病、心肌缺血等的发生发展密切相关。本文主要对SIRT1的基本特征、主要生理作用及其在心血管疾病发生发展中的作用及机制做一综述。

关键词(KeyWords)： 沉默信息调节因子;SIRT1;心血管疾病

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81270168)

作者(Author): 马赛,曹丰

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