封波

• 1:北京大学人民医院肝病科
• 2:北京大学肝病研究所

摘要(Abstract)：

<正>在美国,丙型肝炎病毒(HCV)是经血传播最常见的病原体,是慢性肝病并发症及成人肝移植的主要原因,一般人群中抗-HCV的流行率约为1.6%。根据1999~2008年的资料,大约3/4的HCV感染者出生于1945~1965年,其中1999~2002年间出生的40~49岁人群抗-HCV的流行率达到峰值4.3%[1,2]。研究显示,近来肝细胞癌(HCC)的发生率增加了3倍,其中约一半与其在20~40年

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 封波

参考文献(References)：

• [1]Chou R,Cottrell EB,Wasson N,et al.Screening for hepatitisC virus infection in adults[M].Rockville(MD):Agency forhealthcare research and quality(US):2012,Comparativeeffectiveness review,no.69.
• [2]Smith BD,Patel N,Beckett GA,et al.Hepatitis C virusantibody prevalence,correlates and predictors among personsborn from 1945 through 1965,United States,1999-2008[Abstract][J].Hepatology,2011,54(Suppl 1):554 A-5A.
• [3]Chou R,Wasson N.Blood tests to diagnosis fibrosis or cirrhosisin patients with chronic hepatitis C virus infection:a systematicreview[J].Ann Intern Med,2013,158(11):807-820.
• [4]Chou R,Hartung D,Rahman B,et al.Treatment for hepatitisC virus infection in adults[M].Rockville(MD):Agency forhealthcare research and quality(US):2012,Comparativeeffectiveness review,no.76.
• [5]van der Meer AJ,Veldt BJ,Feld JJ,et al.Association betweensustained virological response and all-cause mortality amongpatients with chronic hepatitis C and advanced hepaticfibrosis[J].JAMA,2012,308(24):2584-2593.
• [6]Morgan RL,Baack B,Smith BD,et al.Eradication of hepatitisC virus infection and the development of hepatocellularcarcinoma:a meta-analysis of observational studies[J].AnnIntern Med,2013,158(5 Pt 1):329-337.
• [7]Kimer N,Dahl EK,Gluud LL,et al.Antiviral therapy forprevention of hepatocellular carcinoma in chronic hepatitis C:systematic review and metaanalysis of randomised controlledtrials[J].BMJ Open,2012,2(5):1-7.
• [8]Liu S,Cipriano LE,Holodniy M,et al.Cost-effectivenessanalysis of risk-factor guided and birth-cohort screening forchronic hepatitis C infection in the United States[J].PLoS One,2013,8(3):e58975.
• [9]U.S.Preventive Services Task Force.Screening for hepatitisC virus infection in adults:recommendation statement[J].AnnIntern Med,2004,140(6):462-464.
• [10]Ghany MG,Strader DB,Thomas DL,et al;AmericanAssociation for the Study of Liver Diseases.Diagnosis,management,and treatment of hepatitis C:an update[J].Hepatology,2009,49(4):1335-1374.
• [11]European Paediatric Hepatitis C Virus Network.Three broadmodalities in the natural history of vertically acquired hepatitisC virus infection[J].Clin Infect Dis,2005,41(1):45-51.
• [12]Dienstag JL,McHutchison JG.American GastroenterologicalAssociation medical position statement on the management ofhepatitis C[J].Gastroenterology,2006,130(1):225-230.
• [13]Smith BD,Morgan RL,Beckett GA,et al.Centers for DiseaseControl and Prevention.Recommendations for the identificationof chronic hepatitis C virus infection among persons bornduring 1945-1965[J].MMWR Recomm Rep,2012,61(RR-4):1-32.
• [14]American Academy of Family Physicians.Clinical PreventiveServices:Hepatitis.Leawood,KS:American Academy ofFamily Physicians;2004[J].Accessed at www.aafp.org/online/en/home/clinical/exam/hepatitis.html on 24 May 2013.